Short Bio. Dr. Krogan was born and raised in Regina, Saskatchewan, Canada and obtained his undergraduate degree from the University of Regina. As a graduate student at the University of Toronto, Dr. Krogan led a project that systematically identified protein complexes in the model organism, Saccharomyces cerevisiae, through an affinity tagging-purification/mass spectrometry strategy. To complement this physical interaction data, Dr. Krogan developed approaches which allows for high-throughput generation and quantitative analysis of genetic interaction data.
Presently, Dr. Krogan’s lab at UCSF focuses on applying these mass spectrometry-based proteomic and CRISPR-focused genetic approaches to a number of organisms and various biological processes, including transcriptional regulation, DNA repair/replication and RNA processing. His lab at UCSF is also developing and applying methodologies to create genetic and physical interactions between pathogenic organisms, including HIV, Mtb, and Dengue, and their hosts, which is providing insight into the human pathways and complexes that are being hijacked during the course of infection. These quantitative and unbiased approaches are also being used in an integrative way to study cancer and neuropsychiatric disorders.