DREAM Challenges and EPIDEMIUM@RECOMB


Dates: 19-20 April, 2018

Scope

The meeting will focus on proteogenomics, single cell systems biology and cancer epidemiology, and how crowdsourced science, data sharing and a culture of collaboration can help advance research in these fields. We will highlight the solutions of the top performing strategies in the Epidemium program in cancer epidemiology and the recent NCI-CPTAC Proteogenomics DREAM Challenge. We will also brainstorm as a community on the possibility of organizing a DREAM challenge on Single Cell Systems Biology.

Topics

(include but not limited to)

  • Proteogenomics
  • Single Cell Systems Biology
  • Cancer epidemiology
  • Crowdsourced science
  • Data sharing

Program

Thursday April 19th
DREAM challenges and EPIDEMIUM@RECOMB I

Friday April 20th
DREAM challenges and EPIDEMIUM@RECOMB II

  • Henry Rodriguez

    -

    Introduction to the Proteogenomics challenge

  • Ruedi Aebersold (Keynote)

    -

    The proteome in context

  • Julio Saez-Rodriguez (DREAM-CPTAC)

    -

    Overview DREAM-CPTAC Proteogenomics Challenge

  • Sunkyu Kim (DREAM-CPTAC)

    -

    Best Method & Collaborative phase Subchallenge 1
    Predicting Protein Abundance using Matrix Factorization and Biological Networks

  • Daniel Quang (DREAM-CPTAC)

    -

    Best Method’s SubChallenge’s 2&3
    Modeling the Determinants of Protein and Phosphoprotein Abundance in Cancers

  • Francesca Petralia (DREAM CPTAC)

    -

    Community Phase of NCI-CPTAC Dream Proteogenomics Sub-Challenge 2 and Sub-Challenge 3

  • Coffee break

    -

  • John Moult

    -

    CAGI and CASP - surprises and lessons

  • David Kreil (TBC)

    -

    CAMDA, an open-ended data analysis challenge of complex data sets

  • Nikolaus Rajewsky (Keynote)

    -

    Single cell sequencing to discover mechanisms of gene regulation

  • Discussion

    -

    Opportunities in single cell data and other emergent data modalities for crowdsourcing

  • Lunch break

    -

    Roam the streets of Paris...

  • Workshop

    -

    Workshop: Designing your collaborative open science campaign

  • Opening reception + Registration

    -

    Open to both RECOMB and satellites participants

Keynote Speakers

Ruedi Aebersold
ETH Zürich, Switzerland

[Short bio/abstract]

Olga Kokshagina
Mines ParisTech, France

Nikolaus Rajewsky
MDC, Germany

Yohann Sitruk
Mines ParisTech, France

Keynote/discussion: Open science with community : pitfalls of organizing collaborative scientific process

  • Context : pitfalls of open science
  • Lessons learned from collaborative open science program Epidemium
  • Iterative scientific process
  • Mechanisms and tools to support successful open science campaign

Workshop: Designing your collaborative open science campaign

A growing amount of scientific research is done in
an open manner. Numerous examples demonstrate that open initiatives
including crowd, citizen- or open science are dealing with more and
more complex problems, moving towards producing more tangible
results. Still, open science approach is not widely used practice by
researchers. Then why is it difficult to create tangible scientific
outputs with crowds? What are the pain points that actors face today
and how to avoid them? How to ensure the success of your open science
initiatives? What is the future of collaborative open science? We
invite you to our collaborative session that brings together
practitioners & researchers. Our goal is to discuss open science
challenges that actors face and to identify together how they can be
solved.

Program:

  • Interactive session : 1. Spot current limits of open science challenges, 2.
    Design your open science campaign : participants and organizers’
    journey
  • Wrap up: On the future of open science and
    collective intelligence approaches

 

Organizers

  • Olivier de Fresnoye (Epidemium)
  • Julio Saez-Rodriguez (RWTH Aachen University)
  • Pablo Meyer-Rojas (IBM)
  • Gustavo Stolovitzky (IBM)
  • Elise Blaese (IBM)

Sponsors